Terpenes and Related Compounds. XII

Some studies in the biosynthesis of terpenes and related compounds.

Cyclic terpenes as a class of natural products display a bewildering array of structural types. Well over a hundred different carbon frameworks have been detected so far, many new substances are being currently added to an already impressive list of compounds, and even several representatives of the long-sought group of sesterterpenes have at last made their appearance on the chemical scene14. ...

Skin sterols. XII. Contrasting effects of certain mercaptans, amines, and related compounds on sterols and sebaceous glands.

The application of carcinogenic hydrocarbons to skin results in a rapid destruction of the seba ceous glands (3, 7, 13), and it has been suggested that a histological screening test for carcinogens might be based upon this phenomenon (13). Inde pendent studies on skin sterols have revealed that the application of carcinogens to rodent skin de creases the amount of A7-cholestenol in the epider m...

Factor XII mutations, estrogen-dependent inherited angioedema, and related conditions

The clinical, biochemical and genetic features of the conditions known as estrogen-dependent inherited angioedema, estrogen-associated angioedema, hereditary angioedema with normal C-1 inhibitor, type III angioedema, or factor XII angioedema are reviewed. Discussion emphasizes pathogenesis, diagnosis, and management.

Coumarins, Xanthones and Related Compounds.

It has long been known that coumarins (α-pyrones) and xanthones (γ-pyrones) together form a large class of naturally occurring compounds exhibiting a wide range of biological activities. However, the interest of the scientific community for these secondary metabolites, as well as for their structural analogues, has never decreased since these “old compounds” are constantly generating promising—...

Pteroylglutamic acid and related compounds.